The goal of the game is clear - to kill all zombies.

The gameplay of Zombieville USA 2 is the same as Zombieville USA, but the difference is that in Zombieville USA 2, the character can move up and down, left and right, and move more flexibly. Players have to control the character's actions in the game to ensure that they can kill the zombies that are approaching in time.

Compared to its predecessor, Zombieville USA 2 has added more characters, players can choose their favorite characters to start the game, some characters need to be purchased by the player to obtain. In addition to characters, this game also adds more weapons to choose from. However, at the beginning of the game, the player only has the simplest weapons, more weapons need to be purchased by the player. Each zombie killed will get a certain amount of money, the more zombies killed, the more money will be obtained. With enough money, players can buy the weapons they like. Weapons can be upgraded, after upgrading weapons will have more lethal power.

During the game, players have the flexibility to change parts. The game will also have bills and bullets while fighting zombies, if the weapon has no bullets, you can use the most primitive stick to hit the zombies. Of course, if there is no weapon that can be used, the player will be eaten by the zombies and end the game.

The game uses the level system, each level has a time limit, the player only in the specified time to survive, can take the rescue helicopter to leave.